Family Economic Strain and Adolescent Aggression during the COVID-19 Pandemic: Roles of Interparental Conflict and Parent-Child Conflict.

Although the link from family economic strain to adolescent aggression has frequently been hypothesized, the results are mixed. Both interparental conflict and parent-child conflict are considered to be potential mediators of this link. However, the empirical evidence supporting this proposition is lacking. The present study investigated the direct effect of family economic strain on adolescent aggression as well as indirect effects through interparental conflict and parent-child conflict. Based on multi-informant data from 971 families with a child in middle and high schools in Y City, in Shanxi Province, structural equation modeling is conducted to examine the proposed theoretical model. Findings show that family economic strain has no significant direct impact on adolescent aggression. Interparental conflict and parent-child conflict mediate the link between family economic strain and adolescent aggression simultaneously and sequentially. This study expands current literature and deepens our understanding of the mechanisms underlying the relationship between family economic strain and adolescent aggression. Implications for policies and interventions to reduce the risk of adolescent aggression are discussed.

Synthetic Neutralizing Peptides Inhibit the Host Cell Binding of Spike Protein and Block Infection of SARS-CoV-2.

Antiviral treatments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been extensively pursued to conquer the pandemic. To inhibit the viral entry to the host cell, we designed and obtained three peptide sequences via quartz crystal microbalance measurement screening, which showed high affinity at nanomole to the S1 subunit of the spike protein and wild-type SARS-CoV-2 pseudovirus. Circular dichroism spectroscopy measurements revealed significant conformation changes of the S1 protein upon encounter with the three peptides. The peptides were able to effectively block the infection of a pseudovirus to 50% by inhibiting the host cell lines binding with the S1 protein, evidenced by the results from Western blotting and pseudovirus luciferase assay. Moreover, the combination of the three peptides could increase the inhibitory rate to 75%. In conclusion, the three chemically synthetic neutralizing peptides and their combinations hold promising potential as effective therapeutics in the prevention and treatment of COVID-19.